pdf book on unani medicine 1.pdf download pdf book on unani medicine by mukti pradhan atgani,.download a method paper on unani medicine pdf download mukti pradhan atgani.pdf book on unani medicine pdf download pdf book on unani medicine by mukti pradhan atgani, pdf download pdf book on unani medicine by mukti pradhan atgani, pdf book on unani medicine 1.pdf download.Gastric electrical stimulation (GES) is a novel, non-pharmacologic, neuromodulatory therapy that is currently approved for management of severe chronic refractory gastroparesis in the United States. GES therapy restores gastric emptying, decreases the symptoms of nausea and vomiting, reduces the use of antiemetic medications, and improves quality of life. However, a recent placebo-controlled trial demonstrated that GES is unlikely to reverse delayed gastric emptying in patients with severe functional dyspepsia. GES is associated with adverse events including oversensing, electrode migration, fracture, and thrombosis. In the general population, approximately 15% of electrodes deliver inappropriate stimulation and deliver inappropriate electrical currents. We have previously demonstrated that the risk of inappropriate therapy delivery can be reduced by lowering the output voltage and/or pulse width of the pulse generator. A biocompatible wireless medical device with customizable output parameters could enable long-term GES therapy for a wide range of patients with various chronic gastrointestinal disorders that presently are not candidates for GES therapy. The current proposal is a proof-of-concept study to demonstrate the safety and efficacy of a wireless, battery-powered, GES pulse generator. The aims of the study are: (1) to refine our current wireless, battery-powered GES system so that it can be safely used in clinical trials, (2) to compare safety and efficacy of a wireless, battery-powered GES system versus placebo for reversal of delayed gastric emptying in humans, (3) to determine the ideal voltage and pulse width to stimulate gastric electrical activity and improve gastric emptying and upper GI symptoms, and (4) to develop a device that will allow us to test other medical devices (e.g. gastric balloons, gastric pacemakers, etc) for the treatment of gastrointestinal diseases. The development of the wireless, battery-powered GES system will ultimately enable its use in clinical trials and may have a major impact 01e38acffe
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